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Overview
Neuronal networks in the brain communicate information about a subject’s intent, internal state, and external environment through electrical activity. Neurological diseases cause one or more of these networks to corrupt this communication, leading to pathological behavior and ultimately early death.
Parkinson's Disease: Closed-Loop Deep Brain Stimulation
Deep brain stimulation (DBS), a neurosurgical treatment that stimulates the brain with electrical signals, is used to treat Parkinson’s disease (PD) and an ever-increasing list of neurological disorders. Despite growing numbers of applications, DBS is at a relative technological standstill due to several factors: limited choice of stimulus waveforms, ability to stimulate at only a single location, and inefficient use of battery power. The only allowable input is a periodic train of square pulses applied in an extremely small region of the brain (a few mm).
BMIs for Fast and Loaded Movements
Brain Machine Interface for High Speed and Loaded Movements:
A Robust Decoder Compensator Architecture
The remarkable ability of monkeys and humans to achieve basic movement control of robot arms using signals extracted from motor cortex has now been amply demonstrated [1]-[5]. However, the controlled movements are in general slow, involve only a few degrees of freedom, and are not dynamically demanding (movements are executed in environments with no disturbances and/or loads). In the future, neuroprosthetics must move as quickly as natural limbs through three dimensions in natural environments.
Featured Publications
2012
- Santaniello S., D. L. Sherman, N. V. Thakor, E. N. Eskandar and S. V. Sarma (2012). "Optimal control-based bayesian detection of clinical and behavioral state transitions." IEEE Trans Neural Syst Rehabil Eng, 20(5): 708-19.
- Agarwal R. and S. V. Sarma (2012).